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Allergy & Immunology

Angioedema

A condition involving deep swelling beneath the skin, often affecting the face, lips, tongue, throat, or extremities, that can occur alongside hives or independently.

Definition

A condition involving deep swelling beneath the skin, often affecting the face, lips, tongue, throat, or extremities, that can occur alongside hives or independently.

In-Depth

What You Need to Know

Angioedema results from fluid leaking into deeper layers of the skin and subcutaneous tissue, producing soft, non-pitting swelling that is often asymmetric and can be disfiguring but is typically not itchy, distinguishing it from the superficial welts of hives. The condition can be allergic (triggered by foods, medications, or insect stings), non-allergic (often caused by ACE inhibitor medications), hereditary (due to C1-esterase inhibitor deficiency), or idiopathic. When angioedema involves the tongue, throat, or larynx, it can become a life-threatening emergency due to potential airway obstruction, requiring immediate administration of epinephrine and emergency medical care. Allergists play a critical role in determining the underlying cause through detailed history, blood tests including complement levels and C1-esterase inhibitor function, and allergy testing when appropriate. Treatment depends on the type of angioedema and may include antihistamines, corticosteroids, epinephrine for acute episodes, and for hereditary angioedema, specialized medications such as C1-esterase inhibitor concentrate, icatibant, or lanadelumab.

Calls & Questions

What Patients Ask

Common phone questions about angioedema — and how Front Desk handles scheduling and call routing automatically.

Common Patient Questions

  • 1What causes sudden swelling of my lips and face?
  • 2Is angioedema the same as an allergic reaction?
  • 3Can my blood pressure medicine cause swelling?
  • 4Should I go to the emergency room for angioedema?

How Front Desk Helps Your Practice

Front Desk assesses the urgency of angioedema-related calls and directs patients with throat or tongue swelling to call 911 immediately, schedules prompt allergy evaluations for patients with new-onset or recurrent angioedema, explains the diagnostic workup process, and coordinates follow-up appointments after emergency department visits for angioedema.

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Related Terms

Learn More

Explore related allergy & immunology terms in our glossary.

FAQ

Frequently Asked Questions

Common questions about angioedema.

A condition involving deep swelling beneath the skin, often affecting the face, lips, tongue, throat, or extremities, that can occur alongside hives or independently. Angioedema results from fluid leaking into deeper layers of the skin and subcutaneous tissue, producing soft, non-pitting swelling that is often asymmetric and can be disfiguring but is typically not itchy, distinguishing it from the superficial welts of hives. The condition can be allergic (triggered by foods, medications, or insect stings), non-allergic (often caused by ACE inhibitor medications), hereditary (due to C1-esterase inhibitor deficiency), or idiopathic.

Your allergy & immunology provider can answer this during your appointment. Front Desk assesses the urgency of angioedema-related calls and directs patients with throat or tongue swelling to call 911 immediately, schedules prompt allergy evaluations for patients with new-onset or recurrent angioedema, explains the diagnostic workup process, and coordinates follow-up appointments after emergency department visits for angioedema.

Your allergy & immunology provider can answer this during your appointment. Front Desk assesses the urgency of angioedema-related calls and directs patients with throat or tongue swelling to call 911 immediately, schedules prompt allergy evaluations for patients with new-onset or recurrent angioedema, explains the diagnostic workup process, and coordinates follow-up appointments after emergency department visits for angioedema.

Your allergy & immunology provider can answer this during your appointment. Front Desk assesses the urgency of angioedema-related calls and directs patients with throat or tongue swelling to call 911 immediately, schedules prompt allergy evaluations for patients with new-onset or recurrent angioedema, explains the diagnostic workup process, and coordinates follow-up appointments after emergency department visits for angioedema.

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